Understanding and discrimination of complex Aldol Reaction
Amigo helps Pharma company quickly identify and clean kill an unsuitable route
A large pharmaceutical company had been investigating a challenging multi-component aldol reaction. The aldol reaction was being evaluated in combination with several other options to assemble richly decorated pharmaceutical intermediate. the group chose to introduce Amigo to the project to obtain better mechanistic understanding. Specifically, Amigo's "Increasing Interval" sampling mode was employed. Here, Amigo automatically doubles the sampling interval throughout the defined reaction time, thus concentrating sampling effort early on.
The group chose to introduce Amigo to the project to obtain better mechanistic understanding. Specifically, Amigo's "Increasing Interval" sampling mode was employed. Here, Amigo automatically doubles the sampling interval throughout the defined reaction time, thus concentrating sampling effort early on.
Data from Amigo sampling
The sample taken at 5mins shows the rapid conversion to the blue intermediate which rapidly converts into the orange and the red intermediate.
The red intermediate was shown to be non-productive giving incorrect stereochemistry
The group immediately killed the route so efforts could be applied to more promising route candidates.
Manual sampling of a reaction of greater than 12 hours duration would rarely include a sampling point at 5 mins. Accordingly, the manual experiment did not uncover this fundamental problem thus wasting precious PRD time.
Other User Case Studies
Amigo Chem is very pleased to learn of the valuable information that its workstation is providing to its users in today’s industrial PRD laboratories.
The Amigo Workstation is now installed in a number of industrial sites; however, you will note that these case studies lack the user name, their company name and any IP sensitive chemistry detail. With resources of our users being limited, seeking permission to publish such material is impractical. However, Amigo Chem hopes that the published case studies will help convey the value of our workstations to the user and their business.
If you have generated any information with your Amigo system that you think will be of interest to others, please do not hesitate to contact us.